Celgene Scientist II In Vitro Drug Metabolism Pharmacokinetics in Summit, New Jersey
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Scientist II is responsible for developing and performing ADME studies, including metabolite characterization; overseeing internal and outsourced DMPK activities; managing the technical aspects of studies; and for preparation of study reports. He/she will work independently to plan, perform and interpret complex experiments.
Responsibilities will also include, but are not limited to, the following:
1.Independently design and conduct in vitro drug metabolism studies in support of drug development programs, and perform additional studies as needed, including metabolite characterization, reaction phenotyping, plasma protein binding, half-life determination, and analytical support of PK studies.
2.Act as technical leader for internal drug metabolism studies performed within the group, especially with regard to mass spectrometry.
3.Work with radiolabeled compounds to facilitate metabolite characterization.
4.Oversee all aspects of internal and outsourced DMPK activities, including method development, study design, protocol and report preparation, and data interpretation.
5.Apply novel techniques and approaches to address DMPK issues.
6.Keep management apprised of project status and current scientific trends using written and oral summaries, as well as presentations.
7.Supervise and/or mentor more junior staff within the group.
8.Participate in preparing Nonclinical Development Work Practices and SOPs.
PhD in Chemistry, Biology or Biochemistry or related field and 3+ years industry experience is preferred. Requires knowledge of drug metabolism and extensive hands-on mass spectrometry experience.
•Broad based understanding of in vitro and in vivo techniques used to characterize drug metabolism, pharmacokinetics and drug interactions potential of drug candidates.
•Strong HPLC and mass spectrometry skills and hands-on experience with LC-MS/MS instrumentation.
•Ability to oversee studies performed internally or at external contract research laboratories.
•Experience working with radiolabeled material is a plus.
•Awareness of regulatory requirements in the areas of drug metabolism, drug-drug interactions, bioanalysis, toxicology, and clinical pharmacology.
•Publications, as the lead author, in peer-reviewed scientific journals.
•Strong written and verbal communication skills and computer proficiency are required.
•Ability to multi-task and work in a collaborative team environment.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
Scientist II In Vitro Drug Metabolism Pharmacokinetics
Location: Summit, NJ, US
Job ID: 17000669