Celgene Associate Scientist, Upstream Process Development in Summit, New Jersey
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
This position in Biologics Process Development is to support the development of high-efficiency upstream processes for recombinant protein production. Reporting to the head of Upstream Process Development Group, the successful candidate will perform mammalian cell culture experiments as well as evaluate other innovative technologies at various scales.
Responsibilities will include, but are not limited to, the following:
1.Conducting small-scale shake flask and bioreactor experiments for cell culture process optimization, which requires some flexible schedule/weekend work.
2.Performing prototype runs at 200L scale for material generation and to test scale-up
3.Investigating and manipulating cellular metabolism for process understanding and improvement
4.Developing in-house cell culture media to achieve high productivity with desired product quality
5.Evaluating process robustness and mitigation strategy for tech transfer and campaign support
6.Working closely with the cell line and downstream development groups for execution of projects
7.Managing laboratory activities such as: equipment set-up, SOP generation, and routine maintenance
8.Supporting new technology assessment including external collaborations
9.Writing technical summaries and development reports for efficient knowledge management
Bio/Chemical Engineering or related field, B.S. with > 4 years industry experience or M.S. with 0-2 years industry experience.
Hands-on experience conducting various industrial cell culture experiments especially bench-top bioreactor operation
Familiarity with equipment used in cell culture processes and troubleshooting
Media development and/or pilot scale experience is a plus
Knowledge of bioreactor characterization and engineering principles
Basic understanding of biochemistry and cell metabolic pathway
Demonstrated ability to collaborate effectively within a team setting
Proficient in computer systems and relevant applications
Statistical application and programming is a plus
Excellent organizational and time management skills
Excellent verbal and written communication skills
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
Associate Scientist, Upstream Process Development
Location: Summit, NJ, US
Job ID: 17000703